Modeling of the process of pore formation during electrical breakdown of bilayer lipid membranes

Targeted drug delivery is one of the most important areas in pharmacology. The can be placed a liposomal shell and destroyed it specific location body using electroporation. In many experiments on study electroporation, bilayer lipid membrane BLM (black film) used as model for action an electric field. characteristic pore size during electroporation several nanometers, which corresponds to thickness. These pores visualized cryoelectron microscopy or atomic force microscopy. However, we cannot observe with help these methods dynamics pores: changes their number over time. We suggest 100-500 nm color film until has turned into black model. Metastable pore-defects about 6 µm were registered film, observed light microscope (video attached, appear at very end recording). temporal characteristics considered: lifetime before rupture, rate increase membrane. results obtained show that thick colored studying process formation